A Guide to the Crucial Role of Cleanrooms in Microbiology Research

A Guide to the Crucial Role of Cleanrooms in Microbiology Research

In the world of microbiology, precision and accuracy are paramount. The significance of controlled environments cannot be overstated. This blog will explore the pivotal role of cleanrooms in this industry and how they’re crucial to the integrity and reliability of microbiological research.

Understanding Microbiology Research

Microbiology research is a multifaceted field dedicated to unraveling the mysteries of microscopic life forms, including bacteria, viruses, fungi, and other microorganisms. Scientists in this field meticulously examine these organisms to discern their structures, functions, and interactions. These investigations are fundamental to advancing medical, environmental, and industrial sciences.

In the pursuit of groundbreaking discoveries, microbiologists engage in an array of experiments, ranging from genetic studies to drug development. This requires a level of precision that exceeds conventional laboratory standards. The success of research relies on the ability to create and maintain environments that shield delicate microorganisms from external disturbances. That’s where cleanrooms come in. 

The Significance of Sterile Conditions in Microbiology Research

The consequences of overlooking cleanrooms in microbiology reverberate throughout the research process, leading to skewed data, compromised experiments, and inaccurate conclusions. Results obtained in cleanrooms are more likely to be reproducible and can be confidently attributed to the targeted microbial elements, free from the interference of contaminants.

Microbiological experiments operate on a microscopic scale, where even the slightest external contaminant can jeopardize the validity of results. Microbes, inherently sensitive to their surroundings, react to changes in environmental conditions with profound implications. Common contaminants include dust particles, airborne microbes, human skin cells, and more. Therefore,  these experiments necessitate a cleanroom – an environment free from unwanted variables, where researchers can control every aspect of the study.

Examples of Common Contaminants in Microbiology and Their Impact:

  1. Dust Particles: Microscopic dust particles can introduce foreign elements into experiments, leading to skewed observations and compromised data reliability.
  2. Airborne Microbes: Microorganisms present in the air pose a constant threat to microbiological research. Uncontrolled airborne contaminants can contaminate cultures, altering microbial behavior and confounding experimental results.
  3. Human Skin Cells: The human body naturally sheds skin cells, and even the slightest contact can introduce genetic material that interferes with the targeted microbial studies.

The Role of Cleanrooms in Microbiology Research

Cleanrooms are controlled environments that maintain exceptionally low levels of airborne particles, contaminants, and pollutants. In microbiology research, cleanrooms provide an environment free from extraneous variables. Cleanrooms adhere to stringent cleanliness standards and ensure everything is up to code and following proper protocols. 

Key Characteristics of Cleanrooms:

  • Controlled Air Quality: Cleanrooms maintain carefully regulated air quality to minimize particle count and microbial presence.
  • Temperature and Humidity Control: Precise control over temperature and humidity levels prevents fluctuations that could impact experimental conditions.
  • Positive Pressure: Cleanrooms often operate under positive air pressure to prevent external contaminants from infiltrating the space.

Design and Construction Considerations for Microbiology Cleanrooms

Designing and constructing cleanrooms for microbiology research is a meticulous process. Factors such as workflow, equipment placement, and ease of maintenance are incorporated to optimize the functionality of the cleanroom.

Features of Microbiology Cleanrooms: 

  • Material Selection: Non-porous and easily cleanable materials are chosen to minimize the risk of particle generation.
  • Airflow Patterns: Well-defined airflow patterns help control particle movement and ensure uniform conditions throughout the cleanroom.
  • Equipment Integration: Integration of specialized equipment and instrumentation within the cleanroom design to support microbiological experiments.
  • High-Efficiency Particulate Air (HEPA) Filters: HEPA filters trap particles as small as 0.3 micrometers, ensuring clean and purified air within the cleanroom.
  • Airlock Entry Systems: Controlled entry and exit points minimize the risk of external contaminants entering the cleanroom.
  • Stringent Protocols: Strict protocols for gowning, hygiene, and behavior inside the cleanroom mitigate the risk of contamination.

Elevate Your Research with Angstrom Technology

At Angstrom Technology, we’re committed to continuous innovation in cleanroom technology. By embracing cutting-edge solutions and emerging trends, we ensure that our cleanrooms are not only state-of-the-art but also adaptable to the evolving needs of microbiological research.

For researchers and institutions seeking to elevate their microbiological research to new heights, Angstrom Technology stands ready to be the trusted partner in cleanroom solutions. We offer tailored cleanroom solutions that align with the unique requirements of your scientific endeavors. Contact us today to discover how we can help you. 

What Are the Key Elements of Custom Cleanroom Solutions? Materials, Layout, Features, and More

What Are the Key Elements of Custom Cleanroom Solutions? Materials, Layout, Features, and More

Across pharmaceuticals, electronics, biotechnology, and beyond, cleanrooms play a pivotal role in safeguarding processes and products from contaminants. Angstrom Technology stands at the forefront of this industry, focusing on tailored designs, cutting-edge innovation, and custom cleanroom solutions?

Are you interested in custom cleanroom solutions? We’ve got you covered. Read on to discover how our cleanrooms can be customized for your needs, including material choices, layout configurations, and more. 

Understanding Customization in Cleanroom Solutions

Customization in cleanroom design is all about tailoring the space to fit the exact needs of an industry or product. Think of it as getting a custom-made suit—it just fits better! 

Tailored solutions are critical because different industries have different standards and needs. Whether it’s pharmaceuticals needing ultra-clean environments or electronics requiring precise temperature control, customization ensures the cleanroom meets those specific demands.

4 Custom Cleanroom Solutions Options:

From materials shaping efficiency to layouts driving productivity, Angstrom Technology offers customized solutions for all your cleanroom needs. 

1. Material Choices

When crafting custom cleanroom solutions, the materials used are like the building blocks, defining the room’s efficiency and functionality. Let’s look at the diverse array of materials used in cleanroom construction and their profound impact. 

Cleanrooms are crafted from an assortment of materials, each with its unique characteristics, including the following:

  • Stainless steel is renowned for its durability and resistance to corrosion, making it ideal for stringent cleanliness standards.
  • Laminates are versatile and customizable, providing a balance between aesthetics and functionality.
  • Polymers offer flexibility and ease of maintenance, often favored for their resistance to chemicals and abrasion.

Cleanrooms are utilized in a wide array of applications and industries, each needing particular materials. For example, pharmaceuticals often opt for materials that ensure superior cleanliness to meet stringent regulatory requirements. Electronics require materials that facilitate controlled environments to safeguard sensitive equipment and processes.

Angstrom Technology boasts a comprehensive range of materials, each offering customizability, optimized functionality, and industry-grade quality. Our expertise lies not just in design, but in strategically selecting and utilizing these materials to create tailored cleanroom solutions that exceed industry expectations.

2. Layout Configurations

The layout of a cleanroom isn’t just about where things go—it’s the blueprint for efficiency. Let’s explore why the format is so crucial and how our team masterfully tailors configurations to elevate operational productivity:

The layout of a cleanroom can make or break efficiency. A thoughtfully designed layout can reduce unnecessary movements, streamline workflow, and enhance productivity. Strategic positioning of machinery and workstations can significantly improve production operations. 

As we discuss cleanroom layouts, it’s important to note that cleanrooms aren’t one-size-fits-all—different arrangements suit different purposes. At Angstrom Technology, we can provide many different floor plan options to suit your needs. 

  • Open floor plans foster flexibility and easy movement within the cleanroom, ideal for dynamic work environments.
  • Modular designs offer scalability and adaptability, allowing for easy expansion or modification.

At Angstrom Technology, the layout isn’t just a plan—it’s a strategic tool for maximizing efficiency and adaptability within custom cleanroom solutions, ensuring all our clients get precisely what they need to excel in their respective industries.

3. Specialized Features

Specialized features are the key to top-of-the-line cleanrooms, elevating their functionality to unmatched levels. Let’s uncover how these innovations take cleanliness and operational excellence to the next level. 

  • HVAC systems maintain precise environmental conditions critical for certain processes, including temperature and humidity control. 
  • Airflow management ensures controlled airflow to prevent contamination and maintain cleanliness levels.
  • HEPA and ULPA filters remove particles as small as 0.3 microns, ensuring ultra-clean air within the cleanroom.
  • Efficient contamination control minimizes airborne particles, crucial for sensitive industries like electronics and aerospace.
  • Real-time monitoring and continuous surveillance ensure adherence to cleanliness standards and prompt response to deviations.
  • Data analytics are used for predictive maintenance, optimizing processes, and ensuring regulatory compliance.

At Angstrom Technology, these specialized features aren’t just add-ons—they’re the backbone of our custom cleanroom solutions. By integrating cutting-edge HVAC systems, advanced filtration technology, state-of-the-art monitoring tools, and more, we ensure every cleanroom we design exceeds expectations and sets new benchmarks for operational excellence.

4. Compliance and Regulatory Standards

Compliance isn’t an option in cleanroom design – it’s mandatory and of the utmost importance. At Angstrom Technology, our custom cleanrooms not only meet but surpass industry regulations and standards, including the following: 

  • ISO Certifications, The International Standards Organization’s classification system, became the official system in 2001. ISO 14644-1 categorizes cleanrooms into Classes 1-9.
  • Federal 209E Standards were replaced by ISO Classes in 2001. The Federal Standards used to categorize cleanrooms into Classes 1-100,000.
  • Some cleanroom applications must comply with additional standards, such as cGMP, that are uniquely tailored to the threats facing their products and processes.

When we build custom solutions, we collaborate closely with our clients to understand their regulatory requirements and ensure seamless compliance. We’re constantly updating designs and practices to stay ahead of regulatory changes and advancements so we can always instill confidence in our clients. 

At Angstrom Technology, cleanroom designs aren’t just about meeting regulations; they’re about setting the bar higher, providing clients with cleanroom solutions that are not only compliant but also innovative, reliable, and future-ready.

Elevate Your Industry Standards with Angstrom Technology

At Angstrom Technology, we don’t just design cleanrooms; we engineer solutions tailored to exceed your expectations. Our commitment to customization goes beyond just fitting the environment—it’s about enhancing productivity, ensuring reliability, and meeting the unique demands of your industry.

Are you ready to elevate your standards? Reach out to Angstrom Technology today and experience the difference tailored cleanroom solutions can make for your industry needs. 

Discover the Importance of Cleanrooms in Life Sciences

Discover the Importance of Cleanrooms in Life Sciences

Angstrom Life Sciences Logo

Life Sciences Cleanrooms


Angstrom Technology is a flexible, turnkey modular provider of cleanrooms, dry rooms, and cold rooms, catering to a wide range of market sectors, including life sciences, healthcare, cell and gene, automotive, aerospace, semiconductor, and food and beverage.

Our clients demand the highest levels of customer service, compliance, quality, and safety. This demand prompted the creation of Angstrom Technology’s Life Sciences Division (ATLSD), which has quickly emerged as a leader in cutting-edge products and services for cleanrooms, dry rooms, and cold rooms. With an unwavering commitment to integrity, quality, innovation, and customer service, Angstrom is dedicated to pushing the boundaries of what’s achievable in the industry, focusing on how integrated teams can provide the best project approach for compliance and success.

Stay in the loop with Angstrom Technology’s Life Sciences Division!

Angstrom Life Sciences Division offers complete optionality, providing our clients with the widest array of systems and products to tailor their spaces precisely to their needs. We made a deliberate choice not to produce our own panels to maintain objectivity, allowing us to present a truly cooperative and seamlessly integrated project approach.

As a national and global company, we possess the capability to provide design-assist, installation, and commissioning and validation services. We work closely with clients, architects, engineers, construction managers, general contractors, and more, ensuring that projects are executed safely with top-notch quality and fully compliant with requirements.

Angstrom Technology boasts in-house technical experts in compliance, ISO levels, cGMP and GMP, cell and gene, CDMO, dry rooms, and environmentally-controlled rooms. This ensures you have access to the full spectrum of choices available in the market.


Angstrom Technology also offers pharmaceutical cleanroom designs with multi-stage air filtration systems that make use of prefilters and HEPA filters, a variety of lighting options from standard to flow through modules, and laminar air flow systems that can be integrated with existing HVAC.


cell and gene therapy cleanroom workstations

The CDCA, a pioneering initiative led by Jennifer Biro, President of Angstrom Technology’s Life Sciences Division, is dedicated to showcasing the latest advancements and trends in cleanroom, dry room, and cold room technologies and products across all market sectors. Supported by industry leaders such as Angstrom Technology, Budd Bioworks, and Colliers, the Cleanroom Design Center of America is a collaborative, innovative, and knowledge exchange hub for all.

Featured Project

Pharma Cleanroom: From Start to Finish

This Angstrom Technology customer works in the pharmaceutical industry and is based in West Michigan. Learn more about this spacious, 32,000 square foot cleanroom project completed in four months’ time!
Azzur Morrisville cleanroom render

Our Life Sciences Cleanroom in Action

Azzur Cleanrooms on Demand™ facility in Morrisville, NC



OEM Packaging Cleanroom





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Biopharma cleanroom validation
















How Can Custom Cleanroom Designs Adapt to My Industry’s Requirements?

How Can Custom Cleanroom Designs Adapt to My Industry’s Requirements?

In today’s world, cleanliness isn’t just a virtue – it’s a necessity. Here at Angstrom Technology, we’re experts in tailoring cleanrooms to meet the unique needs of various industrial applications. From automotive to life sciences and beyond, we’ll explore how custom cleanroom designs can be implemented to meet industry requirements and keep businesses thriving. 

Discover the Vital Role of Cleanroom Designs

Cleanrooms are controlled environments engineered to minimize contamination from particles, microorganisms, and other impurities by precisely regulating air quality, temperature, humidity, and pressure. Achieving this level of control requires meticulous design, construction, and ongoing maintenance. 

Cleanrooms are implemented in a wide array of industries, ranging from pharmaceuticals to aerospace. In some fields, the tiniest of particles or microbes can lead to product defects or health hazards, so cleanrooms have become an invaluable tool.

The need for custom cleanroom designs tailored to industry-specific requirements cannot be overstated. Each sector presents unique challenges, including stringent cleanliness standards and specific regulations. Therefore, a one-size-fits-all approach does not suffice when it comes to cleanrooms. 

Attempting to apply a uniform design to vastly different industries risks compromising the quality and safety of products and can result in regulatory non-compliance. Custom cleanroom designs address these challenges head-on by adapting to the precise needs of each industry. 

To learn more about specific cleanroom classifications and standards, check out our helpful Classifications & Standards page. 

Cleanroom Designs Across Popular Industries:

At Angstrom Technology, we offer dynamic and flexible cleanroom designs, ensuring that your environment aligns seamlessly with the objectives and standards of your industry. We utilize custom designs so you can achieve the highest level of cleanliness, precision, and product integrity. 

Below, we will showcase some of the most popular sectors we work with when creating custom modular cleanrooms. Don’t your field? No worries! We work with many companies that differ from what’s listed below. Email or call our team and discover what we can do for you. 


The pharmaceutical industry relies heavily on cleanrooms for drug manufacturing and research. Sterile environments are paramount to ensure product safety and regulatory compliance.

pharmaceutical cleanroom projectPharmaceutical cleanrooms must adhere to stringent regulations. The industry requires cleanliness down to the molecular level to ensure drug purity and patient safety.

Angstrom Technology Custom Cleanroom Solutions for the Pharmaceutical Industry:

The pharmaceutical industry is subject to heavy government regulation, and pharmaceutical cleanrooms must meet stringent cGMP standards and requirements. You can be assured that Angstrom Technology designs, constructs, and installs the highest-quality pharmaceutical cleanrooms in the business. 


In the automotive sector, cleanrooms are indispensable for manufacturing sensitive components. Precision is the name of the game, as even a speck of dust can impact the performance of critical parts.

automotive projectAutomotive cleanrooms must accommodate a variety of components, from delicate electronic systems to robust engine parts. Each type of component presents its unique contamination challenges.

Angstrom Technology Custom Cleanroom Solutions for the Automotive Industry:

Angstrom Technology designs, builds, and installs top-of-the-line cleanrooms to meet the needs of the automotive industry. Our automotive cleanrooms can meet any classification requirements and are ideally suited for automotive innovation, component manufacturing, and quality testing applications.


Aerospace companies utilize cleanrooms for the production of aircraft components. The slightest impurity could compromise the structural integrity of these parts and have massive effects on production.

aerospace projectAerospace cleanrooms must always meet the regulated levels of the industry. The challenge is maintaining cleanliness while dealing with large and complex parts, as even a tiny defect could have catastrophic consequences.

Angstrom Technology Custom Cleanroom Solutions for the Aerospace Industry:

When it comes to the rigorous cleanroom classifications of the aerospace industry, Angstrom Technology creates the best modular cleanrooms available. All of our cleanroom builds comply with US building and safety codes and are complete with the fixtures and systems you need to use right away. 

Cell and Gene Therapy

A one-size-fits-all approach to cleanrooms drastically falls short when dealing with the intricacies of cell and gene therapy. These revolutionary therapies involve manipulating and administering living cells and genetic materials, making the need for pristine, contamination-free environments paramount. 

Cell and gene therapy have their own distinct set of requirements, including the need for ultra-sterile conditions to ensure patient safety and therapy effectiveness. Custom cleanrooms are designed to tailor to this innovative field’s stringent standards and specialized needs, thereby playing a crucial role in advancing life-saving treatments and ensuring regulatory compliance.

Angstrom Technology Custom Cleanroom Solutions for the Cell and Gene Therapy Industry:

Cell and gene therapies require complex production processes requiring cellular engineering, genetic engineering, growth, and purification. All these operations must be carried out in a controlled environment to ensure safe, reliable, and repeatable results. You can be sure that our cleanrooms meet all the necessary ISO classification requirements. 

Life Sciences

Life sciences is a multifaceted field encompassing many applications, from biotechnology and medical device manufacturing to research and development in genetics and microbiology. Cleanrooms play a pivotal role in maintaining the integrity and innovation of this industry.

biopharma cleanroomCustom cleanrooms provide tailored solutions to cater to the unique needs of each life sciences subsector. They ensure that the environment is precisely aligned with the industry’s specific cleanliness, safety, and operational standards, thereby facilitating groundbreaking research, the production of life-saving therapies, and the advancement of knowledge in the life sciences field.

Angstrom Technology Custom Cleanroom Solutions for the Life Sciences Industry:

The Angstrom Technology Life Sciences Division (ATLSD) has quickly emerged as a leader in cutting-edge products and services for cleanrooms, dry rooms, and cold rooms. We’re dedicated to pushing the boundaries of what’s achievable in the industry, focusing on how integrated teams can provide the best project approach for compliance and success.

Partner with Angstrom Technology for Your Industry-Specific Cleanroom Needs

If you’re seeking tailored cleanroom solutions for your industry, Angstrom Technology is ready to be your dedicated partner in crafting contamination-free environments. Our proven expertise in custom cleanroom designs spans various sectors, ensuring compliance, precision, and product integrity. 

Don’t compromise when it comes to the cleanliness and safety of your operations. Reach out to Angstrom Technology today and discover how we can help you meet your industry-specific cleanroom needs!